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ICD 10 Codes for Neoplasms: Range (C00-D49)

ICD 10 Codes for Neoplasms: Range (C00-D49)

11 Jan 2022
8 min
ICD 10 Codes for Neoplasms: Range (C00-D49)

Neoplasms, commonly known as tumors, are abnormal growths of cells that can either be benign (non-cancerous) or malignant (cancerous). The ICD-10 code C00-D49 is dedicated to classifying and documenting neoplasm growths within the human body. 

This extensive range includes codes for various types of neoplasms, their locations, behavior (benign, malignant, or uncertain), and specific characteristics. Read on to learn about the key diagnosis under each classification. 

ICD-10-CM Code C00-C97: Malignant Neoplasms 

A malignant neoplasm, commonly known as cancer, is a type of abnormal growth or tumor characterized by uncontrolled cell division and the potential to invade surrounding tissues or spread to other parts of the body.

One distinguishing feature of malignant neoplasms is their ability to invade nearby tissues. They can penetrate surrounding structures, causing damage and compromising organ function. 

Furthermore, malignant cells can break away from the primary tumor and travel through the bloodstream or lymphatic system to form secondary tumors in distant organs or tissues—a process known as metastasis.

Key ICD-10-CM Codes for Malignant Neoplasms
ICD Code Description Diagnosis
ICD Code C00 Malignant neoplasm of lip This code represents malignant tumors that originate in the lip. These cancers are often associated with prolonged sun exposure and may occur more frequently in fair-skinned individuals.
ICD Code C16 Malignant neoplasm of stomach Stomach cancer is a malignant tumor that develops in the stomach lining. It can result from various factors, including Helicobacter pylori infection, diet, and genetics.
ICD Code C18 Malignant neoplasm of colon Colon cancer is a common malignancy that affects the colon or large intestine. Risk factors include age, family history, and dietary factors.
ICD Code C34 Malignant neoplasm of bronchus and lung Lung cancer is often associated with tobacco smoking and carcinogen exposure. It includes various types, such as non-small cell lung cancer and small cell lung cancer
ICD Code C50 Malignant neoplasm of breast Breast cancer is a prevalent cancer type in women, characterized by the abnormal growth of breast tissue cells. It can occur in both men and women but is more common in the latter.
ICD Code C53 Malignant neoplasm of cervix uteri Cervical cancer develops in the cervix, often associated with persistent human papillomavirus (HPV) infection. Regular screenings can help with early detection.
ICD Code C56 Malignant neoplasm of ovary Ovarian cancer involves malignant tumors originating in the ovaries. It can be challenging to detect in its early stages.
ICD Code C61 Malignant neoplasm of the prostate Prostate cancer affects the prostate gland in men and is one of the most common cancers among men. Risk factors include age and family history.
ICD Code C67 Malignant neoplasm of bladder Bladder cancer arises in the cells of the bladder lining. Risk factors include smoking and exposure to certain chemicals.

Further Reading:

ICD-10-CM Code D00-D09: In Situ Neoplasms

An in situ neoplasm, also known as carcinoma in situ (CIS), refers to a stage of cancer development in which abnormal cells are found only in the location where they first formed and have not invaded nearby tissues. 

In situ neoplasms are often considered a precancerous or very early cancer stage. While the cells are abnormal, they have not crossed the basement membrane or barrier that separates them from nearby tissues.

Key ICD-10-CM Codes for In Situ Neoplasms
ICD Code Description Diagnosis
ICD Code D00 Carcinoma in Situ of Oral Cavity Carcinoma in situ of the oral cavity refers to the abnormal cells in the mouth that have not yet invaded surrounding tissues.
ICD Code D01 Carcinoma in Situ of Other Digestive Organs Carcinoma in situ of other digestive organs indicates the presence of abnormal cells in the digestive system without invasion into adjacent tissues..
ICD Code D02 Carcinoma in Situ of Middle Ear and Respiratory System Carcinoma in situ of the middle ear and respiratory system involves abnormal cell growth in these areas without infiltration into neighboring structures.
ICD Code D03 Melanoma in Situ Melanoma in situ refers to the early stage of melanoma skin cancer where malignant melanocytes are present only in the epidermis.
ICD Code D04 Carcinoma in Situ of Skin Carcinoma in situ of the skin indicates the presence of abnormal skin cells that have not yet penetrated deeper layers.
ICD Code D05 Carcinoma in Situ of Breast Carcinoma in situ of the breast involves abnormal cell growth in breast ducts or lobules without invasive characteristics..
ICD Code D06 Carcinoma in Situ of Cervix Uteri Carcinoma in situ of the cervix uteri is an early stage of cervical cancer where abnormal cells are confined to the cervical lining.
ICD Code D07 Carcinoma in Situ of Other Female Genital Organs Carcinoma in situ of other female genital organs implies the presence of abnormal cells in these organs without invasion into surrounding tissues.
ICD Code D08 Carcinoma in Situ of Urinary Organs Carcinoma in situ of urinary organs involves abnormal cell growth in the urinary system without spreading to nearby structures.
ICD Code D09 Carcinoma in Situ of Other Sites Carcinoma in situ of other sites encompasses abnormal cell growth in various locations that have not yet invaded neighboring areas.

ICD-10-CM Code D10-D36: Benign Neoplasms 

Benign neoplasms are non-cancerous growths or tumors that arise from abnormal cell proliferation but do not have the capacity to invade nearby tissues or metastasize to distant parts of the body. They are generally considered less aggressive and less harmful than malignant neoplasms. 

Benign neoplasms can occur in extensive tissues and organs, including the skin, soft tissues, glands, and more. Each type of benign neoplasm is assigned a specific code within the D10-D36 range based on its location and characteristics.

Key ICD-10-CM Codes for Benign Neoplasms
ICD Code Description Diagnosis
ICD Code D10 Benign Neoplasm of Mouth and Pharynx Benign neoplasm of the mouth and pharynx refers to non-cancerous growths in the oral and throat areas.
ICD Code D11 Benign Neoplasm of Major Salivary Glands Benign neoplasm of major salivary glands indicates non-malignant growths in the larger salivary glands, such as the parotid gland.
ICD Code D12 Benign Neoplasm of Colon, Rectum, Anus, and Anal Canal Benign neoplasm of the colon, rectum, anus, and anal canal involves non-cancerous growths in the lower digestive tract.
ICD Code D13 Benign Neoplasm of Other Parts of Digestive Tract Benign neoplasm of other parts of the digestive tract encompasses non-malignant growths in various areas of the gastrointestinal system.
ICD Code D14 Benign Neoplasm of Middle Ear and Respiratory System Benign neoplasm of the middle ear and respiratory system indicates non-cancerous growth in these regions.
ICD Code D15 Benign Neoplasm of Other Intrathoracic Organs Benign neoplasm of other intrathoracic organs involves non-malignant growths in the chest area apart from the lungs..
ICD Code D16 Benign Neoplasm of Bone and Articular Cartilage Benign neoplasm of bone and articular cartilage refers to non-cancerous growths affecting bones and joint cartilage.
ICD Code D17 Benign Lipomatous Neoplasms Benign lipomatous neoplasms are non-malignant fatty tissue growths.
ICD Code D18 Hemangioma and Lymphangioma, Any Site Hemangiomas and lymphangiomas are benign neoplasms involving blood vessels or lymphatic vessels and can occur in various body locations.
ICD Code D36 Benign Neoplasm of Other and Unspecified Sites Benign neoplasm of other and unspecified sites encompasses non-cancerous growths in locations not covered by the previous categories.

ICD-10-CM Code D37-D48: Uncertain Behavior Neoplasms

Uncertain Behavior Neoplasms are a category of abnormal tissue growths that exhibit characteristics of a neoplasm (tumor) but with uncertainty regarding whether they are benign (non-cancerous) or malignant (cancerous). These neoplasms have a well-defined histological appearance, meaning their cellular structure and features are identifiable, but their subsequent behavior is difficult to predict.

Key ICD-10-CM Codes for Uncertain Behavior Neoplasms
ICD Code Description
ICD Code D37.0 Neoplasm of uncertain behavior of the oral cavity and digestive organs
ICD Code D37.1 Neoplasm of uncertain behavior of the respiratory and intrathoracic organs
ICD Code D37.2 Neoplasm of uncertain behavior of the bone and articular cartilage
ICD Code D37.3 Neoplasm of uncertain behavior of connective and soft tissue
ICD Code D37.4 Neoplasm of uncertain behavior of skin
ICD Code D37.5 Neoplasm of uncertain behavior of breast
ICD Code D37.6 Neoplasm of uncertain behavior of other specified sites
ICD Code D37.7 Neoplasm of uncertain behavior of endocrine glands and related structures
ICD Code D37.8 Neoplasm of uncertain behavior of overlapping sites
ICD Code D37.9 Neoplasm of uncertain behavior of unspecified site

Further Reading:


Accurate coding of neoplasms within the C00-D49 range is crucial in oncology. It ensures proper patient care, contributes to research, and facilitates fair reimbursement for healthcare providers. By knowing what ICD-10 codes C00-D49 for neoplasms cover, healthcare professionals can advance cancer care through precise documentation.

Disclaimer: The information provided in this blog regarding the International Classification of Diseases (ICD) codes is intended for informational purposes only. We strive to offer accurate and up-to-date content. However, the ICD codes are subject to changes, updates, and modifications by authoritative bodies such as the Centers for Disease Control and Prevention (CDC), the World Health Organization (WHO), and other relevant healthcare organizations. These changes can occur due to advancements in medical knowledge, new diseases, evolving diagnostic criteria, or updates in medical terminology.


  1. What is the purpose of ICD-10 codes for neoplasms in healthcare?

ICD-10 codes for neoplasms serve the purpose of categorizing and coding these conditions accurately, facilitating proper patient care, research, and statistical analysis.

  1. How do ICD-10 codes assist in cancer research and statistics?

ICD-10 codes enable researchers to analyze trends, outcomes, and the effectiveness of cancer treatments, contributing to advancements in cancer research and statistics.

  1. What are the coding challenges associated with rare or unusual neoplasms?

Coding rare or unusual neoplasms can be challenging due to limited documentation and less common diagnostic criteria. Healthcare providers must rely on their expertise and available information.

  1. Are there updates or changes in ICD-10 codes for neoplasms in recent years?

ICD-10 codes are periodically updated to reflect advancements in medical knowledge and changes in disease classification. Healthcare professionals should stay informed about these updates to ensure accurate coding.

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